China (Mainland)
Professional factory cosmetic peptide Lipospondin Formula C21H35N5O4
- FOB Price: USD: 10.00-10.00 /Metric Ton Get Latest Price
- Min.Order: 1 Gram
- Payment Terms: L/C,T/T,Other
- Available Specifications:
top(1-10)Metric Ton
- Product Details
Keywords
- Lipospondin
- Formula C21H35N5O4
- cosmetic peptide
Quick Details
- ProName: Professional factory cosmetic peptide ...
- Molecular Formula: C21H35N5O4
- Appearance: white powder
- Application: cosmetic
- DeliveryTime: 3-5 WORK DAYS
- PackAge: plastic/glass bottle, aluminium foil b...
- Port: chengdu
- ProductionCapacity: 10000 Gram/Week
- Purity: 95% min
- Storage: sealed, keep it in refrigerator at 2-8...
- LimitNum: 1 Gram
Superiority
Chengdu YoungShe
Chemical Co.,Ltd
Chengdu YoungShe Chemical Co Ltd is good cosmetic peptide supplier in China.We are dedicating to the professional, efficient,and reliable partner for global customers on cosmetic peptides. You can select more than 100 kinds of cosmetic peptides here.And we are keeping developing new products and continuously marketing them for sale.
YoungShe Chem provide a one-stop service on cosmetic peptides.It will save you lots of time,energy and money.You will have very pleasant experience with us.Youngshe Chem,your personal cosmetic peptide consult.
Since Dec,2014,YoungShe group has expanded their business to botanical cosmetic active ingredient and related.
We have a professional factory, independent research and
development technology, high efficiency technology
Details
1.Basic information:
Name: Lipospondin
Formula: C21H35N5O4
Molecular:685
Sequence: N-Elaidoyl-KFK
Purity: ≧95%
Grade: cosmetic
Source: synthetic
Stability: stable
Appearance: white powder
MSDS and COA: available for your reference
Delivery: promptly from stock
Appearance: white powder
2.Usage:
prevent age-associated dermal alterations
3.Description：
N-Elaidoyl-KFK as well as KFK were shown to activate LAP-TGF-beta both in vitro, using a solid phase assay with immobilized LAP-TGF-beta, and ex vivo using human dermal fibroblasts cultures. In both assays, as much as up to 10% of LAP-TGF-beta added could be recovered as active form. KQK, KQFK as well as their lipopeptide counterparts were inactive. Elaidyl-KFK-mediated LAP-TGF-beta activation led to up-regulation of collagen and TIMP-1 production and down regulation of PMA-induced MMP-1 expression in fibroblasts cultures. Those effects could be suppressed by supplementing cell culture medium with blocking TGF-beta antibody. Elaidyl-KFK inhibited MMP-2, MMP-9, MMP-3, MMP-1, in vitro with IC(50) equal to 1.2, 1.0, 0.24 and 8.9 microM, respectively. Its ex vivo inhibitory capacity, as assessed using skin tissue sections, towards the elastin-degrading capacity of MMP-9 was even more pronounced. At a 1 microM concentration, the lipopeptide decreased by up to 80% enzyme activity. Thus, "Lipospondin," i.e. elaidyl-KFK might be considered as a promising model compound to prevent age-associated dermal alterations.