China (Mainland)
Cosmetic raw material Lipospondin
- FOB Price: USD: 1.00-1.00 /Metric Ton Get Latest Price
- Min.Order: 1 Gram
- Payment Terms: L/C,T/T,Other
- Available Specifications:
cosmetic(0-500)Metric Ton
- Product Details
Keywords
- Lipospondin
- Lipospondin powder
- N-Elaidoyl-KFK
Quick Details
- ProName: Cosmetic raw material Lipospondin
- Molecular Formula: C21H35N5O4
- Appearance: white powder
- Application: cosmetic raw material
- DeliveryTime: 2~5 working days
- PackAge: glass/plastic bottle protected by bubb...
- Port: Chengdu
- ProductionCapacity: 500 Gram/Week
- Purity: 98%min
- Storage: 2~8 ℃
- Transportation: FedEx/DHL/EMS or by air.
- LimitNum: 1 Gram
- Appearance: White powder
- Samples: available
- Grade: cosmetic
- MSDS/COA: available, pls inquiry
Superiority
Chengdu YoungShe Chemical Co.,Ltd is a dynamic and progressive cosmetic peptides supplier in China. We are dedicating to be a professional, efficient,and reliable partner for global customers on cosmetic peptides. You can select more than 170 kinds of raw cosmetic peptide ingredients here.And we are keeping developing new products and continuously marketing them for sale.
Details
Product Description:
Lipospondin
1.Basic information:
Name: Lipospondin
Formula: C21H35N5O4
Molecular:685
Sequence: N-Elaidoyl-KFK
Purity: ≧95%
Grade: cosmetic
Source: synthetic
Stability: stable
Appearance: white powder
MSDS and COA: available for your reference
Delivery: promptly from stock
Appearance: white powder
2.Usage: prevent age-associated dermal alterations
3.Description：N-Elaidoyl-KFK as well as KFK were shown to activate LAP-TGF-beta both in vitro, using a solid phase assay with immobilized LAP-TGF-beta, and ex vivo using human dermal fibroblasts cultures. In both assays, as much as up to 10% of LAP-TGF-beta added could be recovered as active form. KQK, KQFK as well as their lipopeptide counterparts were inactive. Elaidyl-KFK-mediated LAP-TGF-beta activation led to up-regulation of collagen and TIMP-1 production and down regulation of PMA-induced MMP-1 expression in fibroblasts cultures. Those effects could be suppressed by supplementing cell culture medium with blocking TGF-beta antibody. Elaidyl-KFK inhibited MMP-2, MMP-9, MMP-3, MMP-1, in vitro with IC(50) equal to 1.2, 1.0, 0.24 and 8.9 microM, respectively. Its ex vivo inhibitory capacity, as assessed using skin tissue sections, towards the elastin-degrading capacity of MMP-9 was even more pronounced. At a 1 microM concentration, the lipopeptide decreased by up to 80% enzyme activity. Thus, "Lipospondin," i.e. elaidyl-KFK might be considered as a promising model compound to prevent age-associated dermal alterations.
Shipping:
FedEx/DHL/EMS or by air.
Packaging:
glass/plastic bottle protected by bubble film
Our Services:
More infomation or free sample, feel free to contact us:-)